Review
Nature Reviews Drug Discovery 6, 41-55 (January 2007) | doi:10.1038/nrd2202
There is a Corrigendum (1 February 2007) associated with this article.
Focus on: Antibacterials
Multi-targeting by monotherapeutic antibacterials
Lynn L Silver1 About the author
Abstract
Antibacterial discovery research has been driven, medically, commercially and intellectually, by the need for new therapeutics that are not subject to the resistance mechanisms that have evolved to combat previous generations of antibacterial agents. This need has often been equated with the identification and exploitation of novel targets. But efforts towards discovery and development of inhibitors of novel targets have proved frustrating. It might be that the 'good old targets' are qualitatively different from the crop of all possible novel targets. What has been learned from existing targets that can be applied to the quest for new antibacterials?
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Author affiliations
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LL Silver Consulting, Springfield, New Jersey 07081, USA.
Email: silverly@comcast.net
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