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RB: mitotic implications of a tumour suppressor

Nature Reviews Cancer volume 12, pages 220–226 (2012)Cite this article

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Abstract

RB, a well known tumour suppressor that functions in the control of cell cycle progression and proliferation, has recently been shown to have additional functions in the maintenance of genomic stability, such that inactivation of RB family proteins promotes chromosome instability (CIN) and aneuploidy. Several studies have provided potential explanations for these phenomena that occur following RB loss, and they suggest that this new function of RB may contribute to its role in tumour suppression.

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Figure 1: Mechanisms of CIN.
Figure 2: RB-mediated effects on the progression of S phase through to mitosis.
Figure 3: The CINful path.

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Acknowledgements

We thank D. Compton and L. Kabeche for sharing their unpublished data, N. Ganem for critical reading and suggestions on the manuscript, and the reviewers for their helpful comments. This work was supported by an American Cancer Society Fellowship to A.L.M., the Massachusetts General Hospital Cancer Center Saltonstall Foundation Scholarship to N.J.D., and funding from AstraZeneca and NIH grants GM81607 and CA64402 to N.J.D.

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  1. Amity L. Manning and Nicholas J. Dyson are at the Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA,

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Manning, A., Dyson, N. RB: mitotic implications of a tumour suppressor. Nat Rev Cancer 12, 220–226 (2012). https://doi.org/10.1038/nrc3216

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