Perspective
Nature Reviews Cancer 4, 227-235 (March 2004) | doi:10.1038/nrc1300
Opinion: Cancer as a robust system: implications for anticancer therapy
Hiroaki Kitano1 About the author
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Abstract
Cancers are extremely complex, heterogeneous diseases. Many approaches to anticancer treatment have had limited success — cures are still rare. A fundamental hurdle to cancer therapy is acquired tumour 'robustness'. The goal of this article is to present a perspective on cancer as a robust system to provide a framework from which the complexity of tumours can be approached to yield novel therapies.
Author affiliations
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Hiroaki Kitano is at Sony Computer Science Laboratories, Inc., 3-14-13 Higashi-Gotanda, Shinagawa, Tokyo 141-0022, Japan, and The Systems Biology Institute, Suite 6A, M31, 6-31-15 Jingumae, Shibuya, Tokyo 150-0001 Japan.
Email: kitano@csl.sony.co.jp
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