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Article
Nature Neuroscience  5, 746 - 750 (2002)
Published online: 15 July 2002; | doi:10.1038/nn889

Control of photoreceptor axon target choice by transcriptional repression of Runt

Joshua S. Kaminker1, 5, Jude Canon2, 5, Iris Salecker4 & Utpal Banerjee1, 2, 3

1  Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute, University of California, Los Angeles, California 90095, USA

2  Department of Biological Chemistry, Molecular Biology Institute, University of California, Los Angeles, California 90095, USA

3  Department of Human Genetics, Molecular Biology Institute, University of California, Los Angeles, California 90095, USA

4  Division of Molecular Neurobiology, National Institute for Medical Research, London NW7 1AA, UK

5  These authors contributed equally to this work.

Correspondence should be addressed to Utpal Banerjee banerjee@mbi.ucla.edu
Drosophila photoreceptor neurons (R cells) project their axons to one of two layers in the optic lobe, the lamina or the medulla. The transcription factor Runt (Run) is normally expressed in the two inner R cells (R7 and R8) that project their axons to the medulla. Here we examine the relationship between Run and the ubiquitously expressed nuclear protein Brakeless (Bks), which has previously been shown to be important for axon termination in the lamina. We report that Bks represses Run in two of the outer R cells: R2 and R5. Expression of Run in R2 and R5 causes axonal mistargeting of all six outer R cells (R1−R6) to the inappropriate layer, without altering expression of cell-specific developmental markers.

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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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