Abstract
Circadian organization can be disrupted by constant light, resulting in behavioral arrhythmicity or 'splitting' of rhythms of activity and rest. By imaging molecular rhythms of individual clock neurons in explanted mouse clock nuclei, we now find that constant light desynchronizes clock neurons but does not compromise their ability to generate circadian rhythms. Cellular synchrony within clock nuclei is disrupted during arrhythmicity, whereas neurons in the left and right clock nuclei cycle in antiphase during 'splitting.'
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Acknowledgements
The authors thank T. Page and C. Johnson for thoughtful comments and discussion of the manuscript. Supported by National Institutes of Health grant R01 MH63341 to D.G.M.
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Supplementary information
Supplementary Video 1
Time-lapse video of Per1::GFP activity in SCN from an arrhythmic LL mouse. (MOV 2978 kb)
Supplementary Video 2
Time-lapse video of Per1::GFP activity in SCN from a rhythmic LL mouse. (MOV 3866 kb)
Supplementary Video 3
Time-lapse video of Per1::GFP activity in SCN from a 'split' LL mouse. (MOV 2425 kb)
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Ohta, H., Yamazaki, S. & McMahon, D. Constant light desynchronizes mammalian clock neurons. Nat Neurosci 8, 267–269 (2005). https://doi.org/10.1038/nn1395
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DOI: https://doi.org/10.1038/nn1395
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