Nature Neuroscience
- 9, 1201 - 1203 (2006)
doi:10.1038/nn1006-1201
Turning by asymmetric actinGuo-li Ming
Guo-li Ming is at the Institute for Cell Engineering and in the Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, BRB731, Baltimore, Maryland 21205, USA. gming1@jhmi.edu
Axon guidance requires local protein synthesis at the growth cone. Two new studies show that guidance cues induce asymmetric targeting and translation of  -actin (Actb) mRNA. Such asymmetry may be the mechanism that underlies growth cone turning.
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