Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Sleep and circadian rhythms: do sleep centers talk back to the clock?

Nature Neuroscience volume 6, pages 1005–1006 (2003)Cite this article

A homeostatic control mechanism that monitors and reacts to the need for sleep has been thought to function independently of the brain's circadian clock in previous studies. Now simultaneous recordings of sleep stages and electrical activity in the suprachiasmatic nucleus in behaving animals reveal feedback from sleep centers to the circadian pacemaker.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Possible connections between the circadian pacemaker and the sleep/wake control systems.

References

  1. Borbély, A.A. & Achermann, P. J. Biol. Rhythms 14, 557–568 (1999).

    PubMed  Google Scholar 

  2. Dijk, D.J. & Lockley, S.W. J. Appl. Physiol. 9, 852–862 (2002).

    Article  Google Scholar 

  3. Dijk, D.J., Duffy, J.F. & Czeisler, C.A. Chronobiol. Int. 17, 285–311 (2000).

    Article  CAS  Google Scholar 

  4. Wurts, S.W. & Edgar, D.M. J. Neurosci. 20, 4300–4310 (2000).

    Article  CAS  Google Scholar 

  5. Naylor, E. et al. J. Neurosci. 20, 8138–8143 (2000).

    Article  CAS  Google Scholar 

  6. Dudley, C.A. et al. Science 301, 379–383 (2003).

    Article  CAS  Google Scholar 

  7. Deboer, T., Vansteensel, M.J., Détári, L. & Meijer, J.H. Nat. Neurosci. 6, 1086–1090 (2003).

    Article  CAS  Google Scholar 

  8. Aston-Jones, G., Chen, S., Zhu, Y. & Oshinsky, M.L. Nat. Neurosci. 4, 732–738 (2001).

    Article  CAS  Google Scholar 

  9. Sutcliffe, J.G. & de Lecea, L. Nat. Rev. Neurosci. 3, 339–349 (2002).

    Article  CAS  Google Scholar 

  10. Haas, H. & Panula, P. Nat. Rev. Neurosci. 4, 121–130 (2003).

    Article  CAS  Google Scholar 

  11. Pace-Schott, E.F. & Hobson, J.A. Nat. Rev. Neurosci. 3, 591–605 (2002).

    Article  CAS  Google Scholar 

  12. Saper, C.B., Chou, T.C. & Scammell, T.E. Trends Neurosci. 24, 726–731 (2001).

    Article  CAS  Google Scholar 

  13. Antle, M.C. & Mistlberger, R.E. J. Neurosci. 20, 9326–9332 (2000).

    Article  CAS  Google Scholar 

  14. Kuhlman, S.J., Silver, R., Le Sauter, J., Bult-Ito, A. & McMahon, D.G. J. Neurosci. 23, 1441–1450 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, Laboratory of Circadian Neurobiology, University of California, Los Angeles, Medical School, 760 Westwood Plaza, Los Angeles, 90024, California, USA

    Christopher S Colwell & Stephan Michel

Authors
  1. Christopher S Colwell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephan Michel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Colwell, C., Michel, S. Sleep and circadian rhythms: do sleep centers talk back to the clock?. Nat Neurosci 6, 1005–1006 (2003). https://doi.org/10.1038/nn1003-1005

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1003-1005

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing