Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

GABA puts the brake on stem cells

Nature Neuroscience volume 8, pages 1132–1133 (2005)Cite this article

In the adult brain, new neurons are generated from neural stem cells residing in the subventricular zone. Newborn neuroblasts release the transmitter GABA, which reduces the proliferation of stem cells—and thereby neurogenesis—by a nonsynaptic mechanism.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The production of new neurons in the adult SVZ begins when a neural stem cell (B cell) divides to generate a transit-amplifying cell (C cell).

Ann Thomson

References

  1. Alvarez-Buylla, A. & Lim, D.A. Neuron 41, 683–686 (2004).

    Article  CAS  Google Scholar 

  2. Liu, X., Wang, Q., Haydar, T.F. & Bordey, A. Nat. Neurosci. 8, 1179–1187 (2005).

    Article  CAS  Google Scholar 

  3. LoTurco, J.J., Owens, D.F., Heath, M.J.S., Davis, M.B.E. & Kriegstein, A.R. Neuron 15, 1287–1298 (1995).

    Article  CAS  Google Scholar 

  4. Haydar, T.F., Wang, F., Schwartz, M.L. & Rakic, P. J. Neurosci. 20, 5764–5774 (2000).

    Article  CAS  Google Scholar 

  5. Doetsch, F., Caille, I., Lim, D.A., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Cell 97, 703–716 (1999).

    Article  CAS  Google Scholar 

  6. Stewart, R.R., Hoge, G.J., Zigova, T. & Luskin, M.B. J. Neurobiol. 50, 305–322 (2002).

    Article  CAS  Google Scholar 

  7. Wang, D.D., Krueger, D.D. & Bordey, A. J. Physiol. (Lond.) 550, 785–800 (2003).

    Article  CAS  Google Scholar 

  8. Doetsch, F., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. J. Neurosci. 17, 5046–5061 (1997).

    Article  CAS  Google Scholar 

  9. Kirschenbaum, B., Doetsch, F., Lois, C. & Alvarez-Buylla, A. J. Neurosci. 19, 2171–2180 (1999).

    Article  CAS  Google Scholar 

  10. Bolteus, A.J. & Bordey, A. J. Neurosci. 24, 7623–7631 (2004).

    Article  CAS  Google Scholar 

  11. Represa, A. & Ben-Ari, Y. Trends Neurosci. 28, 278–283 (2005).

    Article  CAS  Google Scholar 

  12. Owens, D.F. & Kriegstein, A.R. Nat. Rev. Neurosci. 3, 715–727 (2002).

    Article  CAS  Google Scholar 

  13. Rivera, C. et al. Nature 397, 251–255 (1999).

    Article  CAS  Google Scholar 

  14. Demarque, M. et al. Neuron 36, 1051–1061 (2002).

    Article  CAS  Google Scholar 

  15. Flint, A.C., Liu, X. & Kriegstein, A.R. Neuron 20, 43–53 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology and the Program in Developmental and Stem Cell Biology, University of California, San Francisco, 94143, California, USA

    Arnold R Kriegstein

Authors
  1. Arnold R Kriegstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kriegstein, A. GABA puts the brake on stem cells. Nat Neurosci 8, 1132–1133 (2005). https://doi.org/10.1038/nn0905-1132

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0905-1132

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing