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Fractalkine: moving from chemotaxis to neuroprotection

Microglia are thought to contribute to neurodegeneration. Now ablating the receptor for the chemokine fractalkine is shown to increase microglial inflammatory response and neuronal death in vivo in several models of CNS insult.

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Figure 1: Fractalkine is primarily expressed by neurons, whereas its G protein–coupled receptor (CX3CR1) is mainly expressed by microglia.

Katie Ris

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Bérangère Ré, D., Przedborski, S. Fractalkine: moving from chemotaxis to neuroprotection. Nat Neurosci 9, 859–861 (2006). https://doi.org/10.1038/nn0706-859

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