Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Disrupting addiction through the loss of drug-associated internal states

Damage to the insula enables some smokers to quit easily and without relapse, reports a recent paper. The lesion may disrupt a a representation of internal bodily urges that is normally cued by learned drug associations.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Drawing and fMRI image of the insula.

References

  1. WHO. World Health Organization, http://www.who.int/tobacco/health_priority/en/print.html (2007).

  2. Balfour, D.J. Nicotine Tob. Res. 6, 899–912 (2004).

    Article  CAS  Google Scholar 

  3. Dani, J.A. & Harris, R.A. Nat. Neurosci. 8, 1465–1470 (2005).

    Article  CAS  Google Scholar 

  4. Naqvi, N.H., Rudrauf, D., Damasio, H. & Bechara, A. Science 315, 531–534 (2007).

    Article  CAS  Google Scholar 

  5. Craig, A.D. Nat. Rev. Neurosci. 3, 655–666 (2002).

    Article  CAS  Google Scholar 

  6. Damasio, A.R. et al. Nat. Neurosci. 3, 1049–1056 (2000).

    Article  CAS  Google Scholar 

  7. Bonson, K.R. et al. Neuropsychopharmacology 26, 376–386 (2002).

    Article  CAS  Google Scholar 

  8. Kilts, C.D. et al. Arch. Gen. Psychiatry 58, 334–341 (2001).

    Article  CAS  Google Scholar 

  9. Everitt, B.J., Dickinson, A. & Robbins, T.W. Brain Res. Brain Res. Rev. 36, 129–138 (2001).

    Article  CAS  Google Scholar 

  10. Kenny, P.J. & Markou, A. J. Neurosci. 25, 6208–6212 (2005).

    Article  CAS  Google Scholar 

  11. Hyman, S.E., Malenka, R.C. & Nestler, E.J. Annu. Rev. Neurosci. 29, 565–598 (2006).

    Article  CAS  Google Scholar 

  12. Schultz, W., Dayan, P. & Montague, P.R. Science 275, 1593–1599 (1997).

    Article  CAS  Google Scholar 

  13. Smolka, M.N. et al. Psychopharmacology (Berl.) 184, 577–588 (2005).

    Article  Google Scholar 

  14. Paterson, N.E., Froestl, W. & Markou, A. Neuropsychopharmacology 30, 119–128 (2005).

    Article  CAS  Google Scholar 

  15. Volkow, N.D., Fowler, J.S., Wang, G.J. & Goldstein, R.Z. Neurobiol. Learn. Mem. 78, 610–624 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dani, J., Montague, P. Disrupting addiction through the loss of drug-associated internal states. Nat Neurosci 10, 403–404 (2007). https://doi.org/10.1038/nn0407-403

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0407-403

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing