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Going small is the new big

Two methods describing gene expression and chromatin profiling of small cell numbers make progress toward achieving comprehensive integrated molecular views of defined cell populations.

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Figure 1: Schematic flow chart of experimental design.

References

  1. Ozsolak, F., Ting, D.T., Wittner, B., Brannigan, B.W., Paul, S. et al. Nat Methods 7, 617–619 (2010).

    Article  Google Scholar 

  2. Adli, M., Zhu, J. & Bernstein, B.E. Nat Methods 7, 613–616 (2010).

    Article  Google Scholar 

  3. Mardis, E.R. & Wilson, R.K. Hum. Mol. Genet. 18, R163–R168 (2009).

    Article  CAS  Google Scholar 

  4. American Association for Cancer Research Human Epigenome Task Force et al. Nature 454, 711–715 (2008).

  5. ENCODE Project Consortium Science 306, 636–640 (2004).

  6. ENCODE Project Consortium et al. Nature 447, 799–816 (2007).

  7. Lipson, D. et al. Nat. Biotechnol. 27, 652–658 (2009).

    Article  CAS  Google Scholar 

  8. Mamanova, L. et al. Nat. Methods 7, 130–132 (2010).

    Article  CAS  Google Scholar 

  9. Ozsolak, F. et al. Nature 461, 814–818 (2009).

    Article  CAS  Google Scholar 

  10. Ozsolak, F. et al. Genome Res. 20, 519–525 (2010).

    Article  CAS  Google Scholar 

  11. Mikkelsen, T.S. et al. Nature 448, 553–560 (2007).

    Article  CAS  Google Scholar 

  12. Attema, J.L. et al. Proc. Natl. Acad. Sci. USA 104, 12371–12376 (2007).

    Article  CAS  Google Scholar 

  13. O'Neill, L.P., VerMilyea, M.D. & Turner, B.M. Nat. Genet. 38, 835–841 (2006).

    Article  CAS  Google Scholar 

  14. Dahl, J.A. & Collas, P. Nucleic Acids Res. 36, e15 (2008).

    Article  Google Scholar 

  15. Goren, A. et al. Nat. Methods 7, 47–49 (2010).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Kornelia Polyak.

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Competing interests

K.P. receives research support from and is a consultant to the Novartis Institute of Biomedical Research, is a consultant to GeneGo Inc, and is a member of the Scientific Advisory Boards of Theracrine, Inc. and Metamark Genetics, Inc..

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Polyak, K. Going small is the new big. Nat Methods 7, 597–600 (2010). https://doi.org/10.1038/nmeth0810-597

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