Two methods describing gene expression and chromatin profiling of small cell numbers make progress toward achieving comprehensive integrated molecular views of defined cell populations.
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References
Ozsolak, F., Ting, D.T., Wittner, B., Brannigan, B.W., Paul, S. et al. Nat Methods 7, 617–619 (2010).
Adli, M., Zhu, J. & Bernstein, B.E. Nat Methods 7, 613–616 (2010).
Mardis, E.R. & Wilson, R.K. Hum. Mol. Genet. 18, R163–R168 (2009).
American Association for Cancer Research Human Epigenome Task Force et al. Nature 454, 711–715 (2008).
ENCODE Project Consortium Science 306, 636–640 (2004).
ENCODE Project Consortium et al. Nature 447, 799–816 (2007).
Lipson, D. et al. Nat. Biotechnol. 27, 652–658 (2009).
Mamanova, L. et al. Nat. Methods 7, 130–132 (2010).
Ozsolak, F. et al. Nature 461, 814–818 (2009).
Ozsolak, F. et al. Genome Res. 20, 519–525 (2010).
Mikkelsen, T.S. et al. Nature 448, 553–560 (2007).
Attema, J.L. et al. Proc. Natl. Acad. Sci. USA 104, 12371–12376 (2007).
O'Neill, L.P., VerMilyea, M.D. & Turner, B.M. Nat. Genet. 38, 835–841 (2006).
Dahl, J.A. & Collas, P. Nucleic Acids Res. 36, e15 (2008).
Goren, A. et al. Nat. Methods 7, 47–49 (2010).
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K.P. receives research support from and is a consultant to the Novartis Institute of Biomedical Research, is a consultant to GeneGo Inc, and is a member of the Scientific Advisory Boards of Theracrine, Inc. and Metamark Genetics, Inc..
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Polyak, K. Going small is the new big. Nat Methods 7, 597–600 (2010). https://doi.org/10.1038/nmeth0810-597
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DOI: https://doi.org/10.1038/nmeth0810-597