Brief Communication abstract
Nature Medicine 13, 1295 - 1298 (2007)
Published online: 28 October 2007 | doi:10.1038/nm1673
B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
Chengyang Liu1,5, Hooman Noorchashm1,5, Jennifer A Sutter2, Mina Naji2, Eline Luning Prak2, Jean Boyer2, Taryn Green1, Michael R Rickels3, John E Tomaszewski2, Brigitte Koeberlein1, Zhonglin Wang1, Michelle E Paessler4, Ergun Velidedeoglu1, Susan Y Rostami1, Ming Yu1, Clyde F Barker1 & Ali Naji1
We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitution after rituximab-mediated depletion was characterized by a preponderance of immature and transitional cells, whose persistence was associated with long-term islet allograft survival. Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy.
- Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
- Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
- Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
- Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
- These authors contributed equally to this work.
Correspondence to: Ali Naji1 e-mail: Ali.Naji@uphs.upenn.edu
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