Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The ABCs of AMD

Nature Medicine volume 3, pages 1196–1197 (1997)Cite this article

The identification of mutations causing age-related macular degeneration paves the way for earlier diagnoses and studies of pathogenic mechanisms.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. National Advisory Eye Council. Vision Research, a National Plan, 1994–1998. NIH publication 933186 (National Institutes of Health, Bethesda, MD, 1993).

  2. Allikmets, R. et al. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277, 1805–1807 (1997).

    Article  CAS  Google Scholar 

  3. Allikmets, R. et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nature Genet. 15, 236–246 (1997).

    Article  CAS  Google Scholar 

  4. Shastry, B.S. Retinitis pigmentosa and related disorders: phenotypes of rhodopsin and peripherin/RDS mutations. Am. J. Med. Genet. 52, 467–474 (1994).

    Article  CAS  Google Scholar 

  5. Azarian, S. & Travis, G. The photoreceptor rim protein is an ABC Transporter encoded by the gene for recessive Stargardt's Disease (ABCR). FEBS Letts. 409, 247–252 (1997).

    Article  CAS  Google Scholar 

  6. Illing, M., Molday, L. & Molday, R. The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily. J. Biol. Chem. 272, 10303–10310 (1997).

    Article  CAS  Google Scholar 

  7. Szuts, E.Z. Light stimulates phosphorylation of two large membrane proteins in frog photoreceptors. Biochemistry 24, 4176–4184 (1985).

    Article  CAS  Google Scholar 

  8. Becq, F. et al. ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic Cells generates a regulated anion flux after expression in Xenopus laevis oocytes. J. Biol. Chem. 272, 2695–2699 (1997).

    Article  CAS  Google Scholar 

  9. Sun, H. & Nathans, J. Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments. Nature Genet. 17, 15–16 (1997).

    Article  Google Scholar 

  10. Papermaster, D.S., Reilly, P. & Schneider, B.G. Cone lamellae and red and green rod outer segment disks contain a large intrinsic membrane protein on their margins: An ultrastructural immunocytochemical study of frog retinas. Vision Res. 22, 1417–1428 (1982).

    Article  CAS  Google Scholar 

  11. Arikawa, K., Molday, R. & Williams, D. Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: Relationship to disk membrane morphogenesis and retinal degeneration. J. Cell Bio. 116, 659–667 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, 75235, USA

    Gabriel H. Travis

  2. F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Jean Bennett

Authors
  1. Gabriel H. Travis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jean Bennett
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Travis, G., Bennett, J. The ABCs of AMD. Nat Med 3, 1196–1197 (1997). https://doi.org/10.1038/nm1197-1196

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1197-1196

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing