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Nature Medicine  3, 1074 - 1075 (1997)
doi:10.1038/nm1097-1074

A chemokine trap for HIV co-receptors

Paolo Lusso

Unit of Human Virology, Department of Biological and Technological, Research (DIBIT), San Raffaele Scientific Institute 20132 Milano, Italy

A novel anti-HIV strategy uses modified chemokines (intrakines), trapped within the endoplasmic reticulum, to block expression of HIV co-receptors on the host cell surface (pages 1110−1116).

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  2. Lusso, P. & Gallo, R.C. Chemokines and HIV infection. Curr. Op. Infect. Dis. 10, 12−17 (1997). | ISI |
  3. Moore, J.P., Trkola, A. & Dragic, T. Co-receptor for HIV-1 entry. Curr Op. Immunol. 9, 450−468 (1997).
  4. Cohen, J. Exploiting the HIV-chemokine nexus. Science 275, 1261−1264 (1997). | Article | PubMed  | ISI | ChemPort |
  5. Chen, J.-D. et al. Inactivation of HIV-1 chemokine co-receptor CXCR4 by a novel intrakine strategy. Nature Med. 3, 1110−1116 (1997). | Article | PubMed  | ISI | ChemPort |
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  7. Feng, Y., Broder, C.C., Kennedy, P.E. & Berger, E.A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272, 872−877 (1996). | PubMed  | ISI | ChemPort |
  8. Scarlatti, G. et al. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Nature Med. in the press.
  9. Yang, A.-G. et al. Phenotypic knockout of chemokine receptor CCR5 by intrakines as a potential therapeutic approach for HIV-1 infection. Proc. Natl. Acad. Sci USA, in the press.
  10. Cocchi, F. et al. Identification of RANTES, MIP-1alpha and MIP-1beta as the major HIV-suppressive factors produced by CD8+ T Cells. Science 270, 1811−1815 (1995). | PubMed  | ISI | ChemPort |
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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