Antibodies that stimulate T-cell costimulatory receptors block progression of established rheumatoid arthritis in a mouse model. No existing therapy arrests disease to such an extent (pages 1088–1094).
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References
Zvaifler, N.J. Am. J. Med. 75, 3–8 (1983).
Seo, S.K. Nat. Med. 10, 1088–1094 (2004).
Pollok, K.E. et al. J. Immunol. 150, 771–781 (1993).
Takahashi, C., Mittler, R.S. & Vella, A.T. J. Immunol. 162, 5037–5040 (1999).
Panayi, G.S. Eur. J. Rheumatol. Inflamm. 5, 423–424 (1982).
Wooley, P.H., Luthra, H.S., Stuart, J.M. & David, C.S. J. Exp. Med. 154, 688–700 (1981).
Munn, D.H. et al. Science 281, 1191–1193 (1998).
Mellor, A.L. et al. J. Immunol. 171, 1652–1655 (2003).
Sun, Y. et al. Nat. Med. 8, 1405–1413 (2002).
Foell, J. et al. J. Clin. Invest. 111, 1505–1518 (2003).
Kwon, B., Lee, H.W. & Kwon, B.S. Trends Immunol. 23, 378–380 (2002).
Mittler, R.S., Bailey, T.S., Klussman, K., Trailsmith, M.D. & Hoffmann, M.K. J. Exp. Med. 190, 1535–1540 (1999).
Kienzle, G. & von Kempis, J. Int. Immunol. 12, 73–82 (2000).
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Mittler, R. Suppressing the self in rheumatoid arthritis. Nat Med 10, 1047–1049 (2004). https://doi.org/10.1038/nm1004-1047
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DOI: https://doi.org/10.1038/nm1004-1047