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Nature Medicine  8, 1075 - 1076 (2002)
doi:10.1038/nm1002-1075

Myelin failure in multiple sclerosis: Breaking the spell of Notch

Reinhard Hohlfeld

Institute for Clinical Neuroimmunology Ludwig Maximilians University, Munich and Department of Neuroimmunology, Max Planck Institute for Neurobiology, Martinsried, Germany hohlfeld@neuro.npg.de

In multiple sclerosis, the myelin sheath is heavily damaged. New evidence suggests that inhibitory signals mediated by the Notch pathway suppress remyelination (pages 1115−1121).

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Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation
Nature Medicine Article (01 Oct 2002)

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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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