Myelin failure in multiple sclerosis: Breaking the spell of Notch
Reinhard Hohlfeld
Institute for Clinical Neuroimmunology Ludwig Maximilians University, Munich and Department of Neuroimmunology, Max Planck Institute for Neurobiology, Martinsried, Germany hohlfeld@neuro.npg.de
In multiple sclerosis, the myelin sheath is heavily damaged. New evidence suggests that inhibitory signals mediated by the Notch pathway suppress remyelination (pages 1115−1121).
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