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Cannabinoid activity curtails cocaine craving

Behavioral studies demonstrate that the central mechanism involved in cocaine relapse is closely linked to the sites where marijuana has its effect, suggesting that cannabinoid receptor antagonists may be used as anti-craving agents. (pages 1151–1154)

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Figure 1: Cocaine craving is thought to be associated with activation of the mesolimbic dopamine system.

Bob Crimii

References

  1. O'Brien, C.P. A range of research based pharmacotherapies for addiction. Science 278, 66–70 (1997).

    Article  CAS  Google Scholar 

  2. De Vries, T.C. et al. A cannabinoid mechanism in relapse to cocaine seeking. Nature Med. 7, 1151–1154 (2001).

    Article  CAS  Google Scholar 

  3. Fattore, L., Martellotta, M.C., Cossu, G., Mascia, M.S. & Fratta, W. CB1 cannabinoid receptor agonist WIN 55,212–2 decreases intravenous cocaine self-administration in rats. Behav. Brain Res. 104, 141–146 (1999).

    Article  CAS  Google Scholar 

  4. Hajos, N., Ledent, C. & Freund, T.F. Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus. Neuroscience (in press).

  5. Piomelli, D., Giuffrida, A., Rodríguez de Fonseca, F. & Calignano, A. The endocannabinoid system as a target for therapeutic drugs. Trends Pharmacol. Sci. 21, 218–224 (2000).

    Article  CAS  Google Scholar 

  6. Giuffrida, A. et al. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. Nature Neurosci. 2, 358–363 (1999).

    Article  CAS  Google Scholar 

  7. Stella, N. & Piomelli, D. Receptor-dependent formation of endogenous cannabinoids in cortical neurons. Eur. J. Pharmacol. 425, 189–196 (2001).

    Article  CAS  Google Scholar 

  8. Kátona, I. et al. Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J. Neurosci. 19, 4544–4558 (1999).

    Article  Google Scholar 

  9. Gallate, J.E. & McGregor, I.S. The motivation for beer in rats: effects of ritanserin, naloxone and SR141716. Psychopharmacology 142, 302–308 (1997).

    Article  Google Scholar 

  10. Colombo, G. et al. Reduction of voluntary ethanol intake in ethanol-preferring SP rats by the cannabinoid antagonist SR-141716. Alcohol Alcohol. 33, 126–130 (1998).

    Article  CAS  Google Scholar 

  11. Shaham, Y., Erb, S. & Stewart, J. Stress-induced relapse to heroin and cocaine seeking in rats: A review. Brain Res. Rev. 33, 13–33 (2000).

    Article  CAS  Google Scholar 

Download references

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Piomelli, D. Cannabinoid activity curtails cocaine craving. Nat Med 7, 1099–1100 (2001). https://doi.org/10.1038/nm1001-1099

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