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A cancer fate in the hands of a samurai

Nature Medicine volume 16, pages 963–965 (2010)Cite this article

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Recent studies show that Musashi-2 (MSI2), a molecule that binds RNA, increases proliferation of normal and malignant blood stem cells. In humans, increased amounts of MSI2 correlate with poor prognosis of leukemia—indicating that MSI2 may be a target to treat this type of cancer.

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Figure 1: Msi2 is a master switch that is 'on' in normal HSCs3,4 and leukemic3,5 stem cells (LSCs), inhibiting translation of Numb mRNA.

Marina Corral

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Authors and Affiliations

  1. Malcolm A.S. Moore is in the Cell Biology Program at the Memorial Sloan-Kettering Cancer Center, New York, New York, USA.,

    Malcolm A S Moore

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  1. Malcolm A S Moore
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Correspondence to Malcolm A S Moore.

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Moore, M. A cancer fate in the hands of a samurai. Nat Med 16, 963–965 (2010). https://doi.org/10.1038/nm0910-963

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