Nature Medicine
10, 902 - 903 (2004)
doi:10.1038/nm0904-902
When good cholesterol goes badAlan M Fogelman
Alan M. Fogelman is at the David Geffen School of Medicine at the University of California, Los Angeles, 10833 Le Conte Avenue, Box 951736, Los Angeles, California 90095-1736, USA. He is also a principal in Bruin Pharma, a start up biotech company. afogelman@mednet.ucla.edu
High density lipoprotein (HDL) is often called the 'good cholesterol.' Products of an inflammatory enzyme, myeloperoxidase, are now shown to selectively target the main protein in HDL, apolipoprotein A-I. This turns the 'good cholesterol' bad.
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