Dieter Nuyens1, Milan Stengl2, Saran Dugarmaa4, Tom Rossenbacker1, Veerle Compernolle1, Yoram Rudy5, Jos F. Smits3, Willem Flameng6, Colleen E. Clancy5, Lieve Moons1, Marc A. Vos2, Mieke Dewerchin1, Klaus Benndorf4, Désiré Collen1, Edward Carmeliet6
& Peter Carmeliet11
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
2
Cardiology, Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, the Netherlands
3
Pharmacology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, the Netherlands
4
Klinikum der Friederich-Schiller-Universität Jena, Institut für Physiologie, Jena, Germany
5
Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio, USA
6
Laboratory of Experimental Cardiac Surgery, KU Leuven, Leuven, Belgium
Correspondence should be addressed to Peter Carmeliet peter.carmeliet@med.kuleuven.ac.be
/+) show the essential LQT3 features and spontaneously develop life-threatening polymorphous ventricular arrhythmias. Unexpectedly, sudden accelerations in heart rate or premature beats caused lengthening of the action potential with early afterdepolarization and triggered arrhythmias in Scn5a
