The development of a primate model, a potential diagnostic test and a novel therapeutic strategy contribute to our understanding of the role of amyloid β in Alzheimer's disease (pages 822–834).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kisilevsky, R. & Fraser, P.E. Aβ amMolyloidogenesis: unique or variation on a systemic theme? Crit. Rev. Biochem. Biol. 32, 361–404 (1997).
Geula, C. et al. Aging renders the brain vulnerable to amyloid β neurotoxicity. Nature Med. 4, 827–831 (1998).
Pitschke, M., Prior, R., Haupt, M. & Riesner, D. Detection of single amyloid β protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nature Med. 4, 832–834 (1998).
Soto, C. et al. β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: potential Alzheimer's therapy. Nature Med. 4, 822–826 (1998).
Kisilevsky, R. & Fraser, P. Proteoglycans and amyloid fibrillogenesis. In The Nature and Origin of Amyloid Fibrils (eds. Bock, C.R. & Goode, J.A.) pp 58–67 (Wiley, Chichester, 1996).
McCubbin, W.D., Kay, CM., Narindrasorasak, S. & Kisilevsky, R. Circular dichroism and fluorescence studies on two murine serum amyloid A proteins. Biochem. J. 256, 775–783 (1988).
De Beer, M.C., De Beer, F.C., McCubbin, W.D., Kay, C.M. & Kindy, M.S. Structural prerequisites for serum amyloid A fibril formation. J. Biol. Chem. 268, 20606–20612 (1993).
Ailles, L., Kisilevsky, R. & Young, I.D. Induction of perlecan gene expression precedes amyloid formation during experimental murine AA amyloidogenesis. Lab. Invest. 69, 443–448 (1993).
Lindahl, B. & Lindahl, U. Amyloid-specific heparan sulfate from human liver and spleen. J. Biol. Chem. 272, 26091–26094 (1997).
Brandwein, S.R., Sipe, J.D., Skinner, M. & Cohen, A.S. Effect of colchicine on experimental amyloidosis in two CBA/J mouse models: chronic inflammatory stimulation and administration of amyloid-enhancing factor during acute inflammation. Lab. Invest. 52, 319–325 (1985).
Kisilevsky, R. et al. Arresting amyloidosis in vivo using small molecule anionic sulphonates or sulphates: implications for Alzheimer's disease. Nature Med. 1, 143–148 (1995).
Caughey, B. & Race, P.E. Potent inhibition of scrapie-associated PrP accumulation by Congo red. J. Neurochem. 59, 768–771 (1992).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kisilevsky, R. Amyloid β threads in the fabric of Alzheimer's disease. Nat Med 4, 772–773 (1998). https://doi.org/10.1038/nm0798-772
Issue Date:
DOI: https://doi.org/10.1038/nm0798-772
This article is cited by
-
Role of Cytosolic Calcium-Dependent Phospholipase A2 in Alzheimer's Disease Pathogenesis
Molecular Neurobiology (2012)
