Mutations in tumour suppressors often lead to tumorigenesis. But other genetic mechanisms affecting suppressor gene expression can be just as effective (pages 686–692).
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References
Knudson, A.G. & Strong, L.C. Mutation and cancer: Statistical study of retinoblastoma. Proc. natn. Acad. Sci. U.S.A. 68, 820–823 (1971).
Merlo, A. et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor pl6/CDKN2/MTSl in human cancers. Nature Med. 1, 686–692 (1995).
Kamb, A. et al. A cell cycle regulator potentially involved in the genesis of many tumor types. Science 264, 436–40 (1994).
Gruis, N.A. et al. Homozygotes for CDKN2 (pl6) germline mutation in Dutch families. Nature Genet. (in the press).
Caldas, C. et al. Frequent somatic mutations and homozygous deletions of the pl6 (MTS1) gene in pancreatic adenocarcinoma. Nature Genet. 8, 27–32 (1994).
Whitaker, N.J. et al. Involvement of RB-1, p53, pl6INK4, and telomerase in immortalization of human cells. Oncogene (in the press).
Leighton, P. et al. Disruption of imprinting Caused by deletion of the H19 gene region in mice. Nature 375, 34–39 (1995).
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Little, M., Wainwright, B. Methylation and p16: Suppressing the suppressor. Nat Med 1, 633–634 (1995). https://doi.org/10.1038/nm0795-633
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DOI: https://doi.org/10.1038/nm0795-633
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