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Dopamine transporter, alcoholism and other diseases

The discovery of dopamine transporter density difference in alcoholics has implications for mechanisms of vulnerability and relapse (pages 654–657).

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References

  1. Tiihonen, J. et al. Altered striatal dopamine re-uptake site densities in habitually violent and nonviolent alcoholics. Nature Med. 1, 654–657 (1995).

    Article  CAS  Google Scholar 

  2. Pickens, R.W. et al. Heterogeneity in the inheritance of Alcoholism. A study of male and female twins. Archs. gen. Psychiat. 48, 19–28 (1991).

    Article  CAS  Google Scholar 

  3. Brunner, H.G., Nelen, M., Breakefield, X.O., Ropers, H.H. & van Oost, B.A. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262, 578–580 (1993).

    Article  CAS  Google Scholar 

  4. Hauser, P. et al. Attention deficit-hyperactivity disorder in people with generalized resistance to thyroid hormone. New Engl. J. Med. 328, 997–1001 (1993).

    Article  CAS  Google Scholar 

  5. Tu, G.C. & Israel, Y. Alcohol consumption by Orientals in North America is predicted largely by a single gene. Behav. Genet. 25, 59–65 (1995).

    Article  CAS  Google Scholar 

  6. Gejman, P. et al. No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. J.A.M.A. 271, 204–208 (1994).

    Article  CAS  Google Scholar 

  7. Goldman, D. et al. D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenylglycol in Finnish and American alcoholics. Acta. psych. Scand. 86, 351–357 (1992).

    Article  CAS  Google Scholar 

  8. Persico, A.M., Vandenburgh, D.J., Smith, S.S. & Uhl, G.R. Dopamine transporter gene polymorphisms are not associated with polysubstance abuse. Biol. Psychiat. 34, 265–267 (1993).

    Article  CAS  Google Scholar 

  9. Byerly, W. et al. Human dopamine transporter gene not linked to schizophrenia in multigenerational pedigrees. Hum. Hered. 43, 319–322 (1993).

    Article  Google Scholar 

  10. Gelernter, J., Kranzler, H.R., Satel, S.L. & Rao, P.A. Genetic association between dopamine transporter alleles and cocaine-induced paranoia. Neuropsychopharmacology 11, 195–200 (1994).

    Article  CAS  Google Scholar 

  11. Cook, E.H. Jr., et al. Association of attention-deficit disorder and the dopamine transporter gene. Am. J. hum. Genet. 56, 993–998 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Rubinstein, P. et al. Genetics of HLA disease associations: the use of the haplotype relative risk (HRR) and the ‘haplo-delta’ (Dh) estimates in juvenile diabetes from three racial groups. Hum. Immun. 3, 384 (1981).

    Article  Google Scholar 

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Goldman, D. Dopamine transporter, alcoholism and other diseases. Nat Med 1, 624–625 (1995). https://doi.org/10.1038/nm0795-624

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