Nature Medicine
8, 662 - 664 (2002)
doi:10.1038/nm0702-662
Extra Rabs unsnarl a lipid traffic jamMartin O. Bergo
& Stephen G. Young
Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco San Francisco, California, USA syoung@gladstone.ucsf.edu
Niemann−Pick type C (NPC) disease is a fatal lipid-storage disorder caused by a 'lipid traffic jam' in late endosomes and lysosomes. A recent study indicates that overexpression of the vesicular transport proteins Rab7 or Rab9 increases the flow of traffic, allowing accumulated lipids to leave the endosomes and reach the Golgi apparatus and endoplasmic reticulum.
|
