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Nature Medicine  8, 564 - 565 (2002)
doi:10.1038/nm0602-564

Releasing the nerve cell killers

Kevin Welch & Junying Yuan

Department of Cell Biology Harvard Medical School Boston, Massachusetts, USA jyuan@hms.harvard.edu

alpha-synuclein promotes apoptosis of dopaminergic neurons − those most affected in Parkinson disease. New research suggests that in these neurons, alpha-synuclein may sequester the 14-3-3 protein, freeing up proteins that promote cell death. (pages 600−606)

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RESEARCH
Dopamine-dependent neurotoxicity of alpha-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
Nature Medicine Article (01 Jun 2002)

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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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