Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Toward trophic treatment in parkinsonism: A primate step

Nature Medicine volume 2, pages 400–401 (1996)Cite this article

GDNF delivery to the brain decreases cardinal symptoms in a monkey model of Parkinson's disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lindsay, R.B. Neuron saving schemes. Nature 373, 289–290 (1995).

    Article  CAS  Google Scholar 

  2. Lin, L.-F. H., Doherty, D.H., Lile, J.D., Bektesh. S. & Collins, F. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopanimergic neurons. Science 260, 1130–1132 (1993).

    Article  CAS  Google Scholar 

  3. Strömberg, I. et al. Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp. Neurol. 124, 401–412 (1993).

    Article  Google Scholar 

  4. Tomac, A. et al. Protection and repair of the nigrostriatal dopaminegic system by GDNF in vivo. Nature 373, 335–339 (1994).

    Article  Google Scholar 

  5. Beck, K.D. et al. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373, 339–341 (1995).

    Article  CAS  Google Scholar 

  6. Hudson, J. et al. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in in vivo. Brain Res. Bull. 36, 425–432 (1995).

    Article  CAS  Google Scholar 

  7. Sauer, H., Rosenblad, C. & Björklund, A. GDNF but not TGF-β3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine-lesion. Proc. Natl. Acad. Sci. USA 92, 8935–8939 (1995).

    Article  CAS  Google Scholar 

  8. Gash, D.M. et al. Functional recovery in GDNF-treated parkinsonian monkeys. Nature 380, 252–255 (1996).

    Article  CAS  Google Scholar 

  9. Arenas, E., Trupp, M., Åkerud, P. & Ib´ñez, C.F. GDNF prevents degeneration and promotes the phe-notype of brain noradrenergic neurons in vivo. Neuron 15, 1465–1473 (1995).

    Article  CAS  Google Scholar 

  10. Henderson, C.E. et al. GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266, 1062–1064 (1994).

    Article  CAS  Google Scholar 

  11. Mount, H.T.J., Dean, D.O., Alberch, J., Dreyfus, C.F. & Black, I.B. Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells. Proc. Natl. Acad. Sci. USA 92, 9092–9096 (1995).

    Article  CAS  Google Scholar 

  12. Ebendal, T., Tomac, A., Hoffer, B.J. & Olson, L. Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia. J. Neurosci. Res. 40, 276–284 (1995).

    Article  CAS  Google Scholar 

  13. Buj-Belio, A., Buchman, V.L., Horton, A., Rosenthal, A. & Davies, A.M. GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15, 821–828 (1995).

    Article  Google Scholar 

  14. Tomac, A. et al. Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult. Proc. Natl. Acad. Sci. USA 92, 9274–8278 (1995).

    Article  Google Scholar 

  15. Sydow, O. et al. Long-term beneficial effects of adrenal medullary autografts supported by nerve growth factor in Parkinson's disease. Eur. J. Neurol. 2, 1–10 (1995).

    Article  Google Scholar 

  16. Olson, L. NGF and the treatment of Alzheimer's disease. Exp. Neurol. 124, 5–15 (1993).

    Article  CAS  Google Scholar 

  17. Gash, D.M. et al. Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. J. Comp. Neurol. 363, 345–358 (1995).

    Article  CAS  Google Scholar 

  18. Kotzbauer, P.T., Lampe, P.A., Johnson, E.M. & Milbrandt, J. Neurturin: A novel neurotrophic factor related to GDNF. [Poster replacing Soc. Neurosci. Abstr. 21 (part 1), 544 (1995)].

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neuroscience, Karolinska Institute, Stockholm, S-171 77, Sweden

    Lars Olson

Authors
  1. Lars Olson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Olson, L. Toward trophic treatment in parkinsonism: A primate step. Nat Med 2, 400–401 (1996). https://doi.org/10.1038/nm0496-400

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0496-400

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing