Abstract
“A mouse is miracle enough to stagger sextillions of infidels” Leaves of Grass, Walt Whitman The mouse has become our experimental surrogate. It is the creature we turn to to do the experiments, so important in reaching an understanding of ourselves, that are either technically impossible or morally inconceivable in human subjects.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Jacobs, H.J. et al. A genetic linkage map of the laboratory rat, Rattus norvegicus . Nature. Genet. 9, 63–69 (1995).
Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994).
Davison, M.T. et al. Segmental trisomy as a mouse model for Down syndrome. in The Phenotypic Mapping of Down Syndrome. and Other Aneuploid Conditions 117–133 (Wiley-Liss, New York, 1993).
Nishina, P.M., Johnson, J.P., Naggert, J.K. & Krauss, R.M. Linkage of atherogenic lipoprotein phenotype to the low density lipoprotein receptor locus on the short arm of chromosome 19. Proc. natn. Acad. Sci U.S.A. 89, 708–712 (1992).
Paigen, B. et al. Ath-1, a gene determining atherosclerosis susceptibility and high density lipoportein levels in mice. Proc. natn. Acad. Sci. U.S.A. 84, 3763–3767 (1987).
Paigen, B. Genetics of reponsiveness to high cholesterol and high fat diets in the mouse. Am. J. Clin. Nutr. (in the press).
Coleman, D.L. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141–148 (1978).
Sly, W.S. Gene therapy on the Sly. Nature Genet. 4, 105–106 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Paigen, K. A miracle enough: the power of mice. Nat Med 1, 215–220 (1995). https://doi.org/10.1038/nm0395-215
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0395-215
This article is cited by
-
Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible electroporation
Scientific Reports (2021)
-
Generation of genetically-engineered animals using engineered endonucleases
Archives of Pharmacal Research (2018)
-
Isolated heart models: cardiovascular system studies and technological advances
Medical & Biological Engineering & Computing (2015)
-
Non-invasive in vivo measurement of cardiac output in C57BL/6 mice using high frequency transthoracic ultrasound: evaluation of gender and body weight effects
The International Journal of Cardiovascular Imaging (2014)
-
Impact of the Environment on the Skeleton: Is it Modulated by Genetic Factors?
Current Osteoporosis Reports (2013)