Regulatory T cells (Tregs) have gone from obscurity to rock-star status in the past decade, prompting intense scrutiny—but what exactly are they? Four studies examine this question, delving deeply into the role of the transcription factor Foxp3 in governing Treg differentiation and function.
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Curiel, T. Regulatory T-cell development: is Foxp3 the decider?. Nat Med 13, 250–253 (2007). https://doi.org/10.1038/nm0307-250
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DOI: https://doi.org/10.1038/nm0307-250
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