Magnesium sulfate administered to pregnant mothers may reduce the risk of cerebral palsy in very preterm infants.
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References
Andrews, W.W., Coldenberg, R.L. & Hauth, J.C. Preterm labor: Emerging role of genital tract infections. Infect. Agents Dis. 4, 196–211 (1995).
Schendel, D.E., Berg, C.J., Yeargin-Allsopp, M., Boyle, C.A. & Decoufle, P. Prenatal magnesium sulfate exposure and the risk for cerebral palsy or mental retardation among very low-birth-weight children aged 3 to 5 years. JAMA 276, 1805–1810 (1996).
Saigal, S., Szatmari, P., Rosenbaum, P., Campbell, D. & King, S. Cognitive abilities and school performance of extremely low birth weight children and matched term control children at age 8 years: A regional study. J. Pediatr. 118, 751–760 (1991).
McDonald, J.W., Silverstein, F.S. & Johnston, M.V. Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Neurosci. Lett. 109, 234–238 (1990).
Nelson, K.B. & Grether, J.K. Can magnesium sulphate reduce the risk of cerebral palsy in very low birth weight infants? Pediatrics 95, 263–269 (1995).
Yoon, B.H. et al. High expression of interleukin-6, interleukin-1, and tumor necrosis factor in periventricular leukomalacia. Am. J. Obstet. Gynecol. SPO Abstr. 174, 319–399 (1996).
Weglicki, W.B., Phillips, T.M., Freedman, A.M., Cassidy, M.M. & Dickens, B.F. Magnesium deficiency elevates circulating levels of inflammatory cytokines and endothelin. Mol. Cell. Biochem. 110, 169–173 (1992).
Kass, E.H., Schlievert, P.M., Parsonnet, J. & Mills, J.T. Effect of magnesium on production of toxic-shock-syndrome toxin-1: A collaborative study. J. Infect. Dis. 158, 44–51 (1988).
Blair, E., Palmer, L. & Stanely, F. Cerebral palsy in very low birthweight infants, pre-eclampsia and magnesium sulfate. Pediatrics 97, 780–781 (1996).
Rouse, D.J., Hauth, J.C., Nelson, K.G. & Goldenberg, R.L. The feasibility of a randomized clinical perinatal trial: Maternal magnesium sulfate for the prevention of cerebral palsy. Am. J. Obstet. Gynecol. 175, 701–705 (1996).
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Goldenberg, R., Rouse, D. Preterm birth, cerebral palsy and magnesium. Nat Med 3, 146–147 (1997). https://doi.org/10.1038/nm0297-146
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DOI: https://doi.org/10.1038/nm0297-146
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