Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements
Focuses
Guide to authors
Online submissionOnline submission
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
Reprints and permissions
About this site
For librarians
 
NPG Resources
Nature
Nature Reviews
Nature Immunology
Nature Cell Biology
Nature Genetics
news@nature.com
Nature Conferences
Dissect Medicine
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
News and Views
Nature Medicine  3, 17 - 18 (1997)
doi:10.1038/nm0197-17

Live-attenuated HIV vaccines: How safe is safe enough?

Michael Murphey-Corb

Tulane Regional Primate Research Center, 18703 Three Rivers Road, Covington, Louisiana 70433, USA

A live-attenuated SIV vaccine inducing protection in healthy adult monkeys appears both safe and effective but may be lethal when given in high doses to newborns (pages 32−36).

REFERENCES
  1. Warren, J.T. & Levinson, M.A. Fourth annual survey of worldwide HIV, SIV, and SHIV challenge studies in vaccinated nonhuman primates. J. Med. Primatol. 24, 150−168 (1995). | PubMed  | ISI | ChemPort |
  2. Daniel, M.D., Kirchhoff, F., Czajak, S.C., Sehgal, P.K. & Desrosiers, R.C. Protective effects of a live-attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938−1941 (1992). | PubMed  | ISI | ChemPort |
  3. Wyand, M.S., Manson, K.H., Garcia-Moll, M., Montefiori, D. & Desrosiers, R.C. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J. Virol. 70, 3724 (1996). | PubMed  | ISI | ChemPort |
  4. Clements, J.E. et al. Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus. J. Virol. 69, 2737−2744 (1995). | PubMed  | ISI | ChemPort |
  5. Lohman, B.L. et al. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. J. Virol. 68, 7021−7029 (1994). | PubMed  | ISI | ChemPort |
  6. Baba, T.W. et al. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267, 1820−1825 (1995). | PubMed  | ISI | ChemPort |
  7. Gibbs, J.S., Regier, D.A. & Desrosiers, R.C. Construction and in vitro properties of SIVmac mutants with deletions in the "nonessential" genes. AIDS Res. Hum. Retroviruses 10, 607−616 (1994). | PubMed  | ISI | ChemPort |
  8. Wyand, M., Manson, K.H., Lackner, A.A. & Desrosiers, R.C. Resistance of neonatal monkeys to live-attenuated vaccine strains of simian immunodeficiency virus. Nature Med. 3, 32−36 (1997). | Article | PubMed  | ISI | ChemPort |
 Top
 Top
References
Previous | Next
Table of contents
Download PDFDownload PDF
Send to a friendSend to a friend
Save this linkSave this link
References
Export citation
Export references
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | For authors | Online submission | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | Reprints and permissions | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©1997 Nature Publishing Group | Privacy policy