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Breaking the rules of cancer

Nature Medicine volume 12, pages 14–15 (2006)Cite this article

A cancer genetics dogma states that hematologic malignancies arise as a result of defined chromosomal translocations, whereas mutations underlie epithelial solid tumors. This rule is now broken in an analysis of chromosomal translocations in prostate cancer.

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Figure 1: Chromosomal translocations in a solid tumor.

References

  1. Nowell P. & Hungerford, D. J. Natl. Cancer Inst. 25, 85–109 (1960).

    CAS  PubMed  Google Scholar 

  2. Rowley, J.D. Nature 243, 290–293 (1973).

    Article  CAS  PubMed  Google Scholar 

  3. Lugo, T.G., Pendergast, A.M., Muller, A.J. & Witte, O.N. Science 247, 1079–1082 (1990).

    Article  CAS  PubMed  Google Scholar 

  4. O'Brien, S.G. et al. N. Engl. J. Med. 348, 994–1004 (2003).

    Article  CAS  PubMed  Google Scholar 

  5. Pandolfi, P.P. Oncogene 20, 3116–3127 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Tomlins, S.A. et al. Science 310, 644–648 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Delattre, O. et al. N. Engl. J. Med. 331, 294–299 (1994).

    Article  CAS  PubMed  Google Scholar 

  8. Petrovics, G. et al. Oncogene 24, 3847–3852 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. Trotman, L.C. et al. PLoS Biol. 1, E59 (2003).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Chen, Z. et al. Nature 436, 725–730 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Cairns, P. et al. Cancer Res. 57, 4997–5000 (1997).

    CAS  PubMed  Google Scholar 

  12. Oikawa, T. & Yamada, T. Gene 303, 11–34 (2003).

    Article  CAS  PubMed  Google Scholar 

  13. Tremblay, F. & Marette, A. J. Biol. Chem. 276, 38052–38060 (2001).

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Medicine, Genitourinary Oncology Service, Memorial Sloan-Kettering Cancer Center,

    David R Shaffer

  2. Department of Pathology, Cancer Biology and Genetics Program, Sloan-Kettering Institute, Graduate School of Medical Sciences, Cornell University, New York, 10021, New York, USA

    Pier Paolo Pandolfi

Authors
  1. David R Shaffer
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  2. Pier Paolo Pandolfi
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Shaffer, D., Pandolfi, P. Breaking the rules of cancer. Nat Med 12, 14–15 (2006). https://doi.org/10.1038/nm0106-14

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