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Finding a sirtuin truth in Huntington's disease

Nature Medicine volume 18, pages 24–26 (2012)Cite this article

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The search for compounds to treat neurodegenerative disorders is especially pressing given the rapidly growing elderly human population and has led to the consideration of sirtuin proteins as potential therapeutic candidates. Two studies now report that modulating the expression of the sirtuin Sirt1 has therapeutic benefit in Huntington's disease mouse models and identify putative downstream targets of Sirt1 involved in improved disease outcomes (pages 159–165 and 153–158).

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Figure 1: Inhibition of Sirt1 contributes to Huntington's disease pathogenesis.

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Authors and Affiliations

  1. Albert R. La Spada is in the Departments of Pediatrics, Division of Biological Science, Cellular & Molecular Medicine, and Neurosciences, University of California–San Diego, La Jolla, California, USA, and the Institute for Genomic Medicine, University of California–San Diego, La Jolla, California, USA.,

    Albert R La Spada

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  1. Albert R La Spada
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Correspondence to Albert R La Spada.

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La Spada, A. Finding a sirtuin truth in Huntington's disease. Nat Med 18, 24–26 (2012). https://doi.org/10.1038/nm.2624

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