Nature Immunology
3, 477 - 482 (2002)
Published online: 15 April 2002; | doi:10.1038/ni789
There is a Corrigendum (April 2003) associated with this Article.
A neuronal receptor, neuropilin-1, is essential for the initiation of
the primary immune responseRafaèle Tordjman1, Yves Lepelletier2, Valérie Lemarchandel1, Marie Cambot1, Philippe Gaulard3, Olivier Hermine2
& Paul-Henri Roméo11
Institut Cochin, Departement d'Hematologie, INSERM
U567, CNRS UMR 8104, Paris, France. 2
CNRS UMR 8603 and Service d'Hematologie,
Hôpital Necker, Paris, France. 3
Département de Pathologie EA 2348,
Hôpital Henri Mondor, Créteil,
France.
Correspondence should be addressed to Rafaèle Tordjman tordjman@cochin.inserm.fr or Olivier Hermine hermine@necker.frThe initiation of a primary immune response requires contact
between dendritic cells (DCs) and resting T cells. However, little is known
about the proteins that mediate this initial contact. We show here that
neuropilin-1, a receptor involved in axon guidance, was expressed by human DCs
and resting T cells both in vitro and in vivo. The initial
contact between DCs and resting T cells led to neuropilin-1 polarization on T
cells. DCs and resting T cells specifically bound soluble neuropilin-1, and
resting T cells formed clusters with neuropilin-1−transfected COS-7 cells
in a neuropilin-1−dependent manner. Functionally, preincubation of DCs or
resting T cells with blocking neuropilin-1 antibodies inhibited DC-induced
proliferation of resting T cells. These data suggest that neuropilin-1 mediates
interactions between DCs and T cells that are essential for initiation of the
primary immune response and show parallels between the nervous and immune
systems.
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