Article abstract
Nature Immunology 9, 54 - 62 (2008)
Published online: 25 November 2007 | doi:10.1038/ni1542
Follicular shuttling of marginal zone B cells facilitates antigen transport
Guy Cinamon1, Marcus A Zachariah1, Olivia M Lam1, Frank W Foss, Jr2,3 & Jason G Cyster1
Abstract
The splenic marginal zone is a site of blood flow, and the specialized B cell population that inhabits this compartment has been linked to the capture and follicular delivery of blood-borne antigens. However, the mechanism of this antigen transport has remained unknown. Here we show that marginal zone B cells were not confined to the marginal zone but continuously shuttled between the marginal zone and follicular areas, such that many of the cells visited a follicle every few hours. Migration to the follicle required the chemokine receptor CXCR5, whereas return to the marginal zone was promoted by the sphingosine 1-phosphate receptors S1P1 and S1P3. Treatment with an S1P1 antagonist caused displacement of marginal zone B cells from the marginal zone. Marginal zone–follicle shuttling of marginal zone B cells provides an efficient mechanism for systemic antigen capture and delivery to follicular dendritic cells.
- Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA.
- Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.
- Present address: Department of Chemistry, Columbia University, New York, New York 10027, USA.
Correspondence to: Jason G Cyster1 e-mail: jason.cyster@ucsf.edu
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