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Limiting inflammatory responses during activation of innate immunity

Nature Immunology volume 6, pages 1198–1205 (2005)Cite this article

Abstract

The idea of the importance of mounting an inflammatory response for effective immunity is supported by a multiplicity of experimental data. It is also well understood that resolution of inflammation is essential for maintaining the balance between health and disease. When the normal regulatory mechanisms are disturbed, the potential for developing chronic inflammatory diseases is increased. Inflammation is a key element in the response of the innate immune system to a variety of challenges, including those provided by bacterial and viral infection as well as by damaged or dying host cells. Here we review elements of innate immunity that lead to inflammation and some of the host mechanisms that allow for the resolution of the inflammatory responses.

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Figure 1: Receptors of the innate immune system.
Figure 2: Control of the expression of inflammatory genes.
Figure 3: Inhibition of TLR signaling by endogenous proteins.

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Acknowledgements

Supported by the National Institutes of Health (AI15136, GM28485, AI54523, GM37696, AI41637, AI54796 and GM67101).

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  1. The Key Laboratory of The Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, 361005, China

    Jiahuai Han

  2. Department of Immunology, The Scripps Research Institute, La Jolla, 92037, California, USA

    Jiahuai Han & Richard J Ulevitch

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Correspondence to Jiahuai Han.

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Han, J., Ulevitch, R. Limiting inflammatory responses during activation of innate immunity. Nat Immunol 6, 1198–1205 (2005). https://doi.org/10.1038/ni1274

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