University of Sheffield Division of Clinical Sciences, Northern General Hospital, Sheffield S5 7AU, UK. (k.f.watson@sheffield.ac.uk)
Graves' disease and other autoimmune syndromes affecting the thyroid are the archetypes of organ-specific autoimmunity. Despite intensive research, the relative contribution of genetic and environmental factors to disease pathogenesis is not clear. Here, the latest developments in understanding the determinants of these diseases are discussed.
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