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NLRs and the dangers of pollution and aging

The production of inflammatory interleukin 1β after uptake of silica crystals and alum salt or amyloid-β occurs by a process that involves lysosomal destabilization and release of cathepsin B that activates the NLRP3 inflammasome.

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Figure 1: Lysosomal permeabilization activates the NLRP3 inflammasome.

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Willingham, S., Ting, JY. NLRs and the dangers of pollution and aging. Nat Immunol 9, 831–833 (2008). https://doi.org/10.1038/ni0808-831

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