Pamela J. Fink is in the Department of Immunology, University of Washington, HSB-I607H, Campus Box 357650, Seattle, Washington 98195, USA. pfink@u.washington.edu
Commitment by thymocytes to a CD4 or a CD8 lineage depends on T cell receptor−mediated intracellular signaling cues. But new data indicate that T cell lineage fate may also be influenced by the frequency of nonselected cells in the thymic microenvironment during development.
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