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Gaining entry to an uninflamed brain

Little is known about how pathogenic T cells gain access to the uninflamed brain in multiple sclerosis and experimental autoimmune encephalomyelitis. A new study reports that interleukin 17–producing T helper cells enter the uninflamed central nervous system through the choroid plexus by a CCR6-CCL20–dependent mechanism.

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Figure 1: CCR6-dependent entry into the CNS.

Kim Caesar

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Axtell, R., Steinman, L. Gaining entry to an uninflamed brain. Nat Immunol 10, 453–455 (2009). https://doi.org/10.1038/ni0509-453

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