News and Views
Nature Immunology 8, 481 - 483 (2007)
doi:10.1038/ni0507-481
Giving B cell tolerance the 'TSLiP'
- David Allman and Dan Northrup are in the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. e-mail: dallman@mail.med.upenn.edu
Abstract
Self-reactive B cells are subject to several mechanisms to ensure self-tolerance. The epithelium-derived cytokine TSLP acts to regulate B cell tolerance by targeting B cell precursors rather than mature B cells.
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