News and Views
Nature Immunology 8, 479 - 481 (2007)
doi:10.1038/ni0507-479
Epithelial NF-
B maintains host gut microflora homeostasis
Yinon Ben-Neriah1 & Marc Schmidt-Supprian2
- Yinon Ben-Neriah is with The Lautenberg Center for Immunology, Hebrew University–Hadassah Medical School, Jerusalem 91220, Israel. e-mail: yinon@cc.huji.ac.il
- Marc Schmidt-Supprian is with the CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA.
Abstract
Epithelial NF-
B preserves the integrity of the gut epithelial barrier and coordinates the antimicrobial actions of the innate and adaptive immune systems. Deficiency in or hyperactivation of this transcription factor results in chronic inflammatory bowel disease.
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