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Switching sides: transcriptional control of CD4 thymocyte lineage commitment

Nature Immunology volume 6, pages 363–364 (2005)Cite this article

Double-positive thymocytes are selected into the CD4 or CD8 lineage on the basis of their T cell receptor specificity. The transcription factor cKrox has been identified as being both required and sufficient to direct thymocytes undergoing positive selection to the CD4 lineage.

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Figure 1: Expression of the transcription factor cKrox is required for differentiation of immature thymocytes to the CD4 lineage.

Katie Ris

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  1. Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 4RD, UK

    Rose Zamoyska

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  1. Rose Zamoyska
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Zamoyska, R. Switching sides: transcriptional control of CD4 thymocyte lineage commitment. Nat Immunol 6, 363–364 (2005). https://doi.org/10.1038/ni0405-363

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