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In vivo veritas: the surprising roles of Fc receptors in immunity

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Jeffrey Ravetch describes how he came to identify the in vivo function of the once mysterious Fc receptors.

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References

  1. Berken, et al. J. Exp. Med. 123, 119–144 (1966).

    Article  CAS  Google Scholar 

  2. Ravetch, J.V. in Fundamental Immunology 5th edn. (ed. Paul, W.) (Lippincott-Raven, Philadelphia-New York, 2003).

    Google Scholar 

  3. Nimmerjahn, et al. Nat. Rev. Immunol. 8, 34–47 (2008).

    Article  CAS  Google Scholar 

  4. Nimmerjahn, et al. Curr. Opin. Immunol. 19, 239–245 (2007).

    Article  CAS  Google Scholar 

  5. Hessell, et al. Nature 449, 101–104 (2007).

    Article  CAS  Google Scholar 

  6. Verma, et al. Clin. Vaccine Immunol. 16, 1405–1412 (2009).

    Article  CAS  Google Scholar 

  7. Janeway, C.A. in Immunobiology 1st edn. (Elsevier, New York, 1994).

    Google Scholar 

  8. Janeway, C.A. in Immunobiology 4th edn. (Elsevier, New York, 1999).

    Google Scholar 

  9. Ravetch, et al. Cell 27, 583–591 (1981).

    Article  CAS  Google Scholar 

  10. Ravetch, et al. Proc. Natl. Acad. Sci. USA 77, 6734–6738 (1980).

    Article  CAS  Google Scholar 

  11. Unkeless, J.C. J. Exp. Med. 150, 580–596 (1979).

    Article  CAS  Google Scholar 

  12. Ravetch, et al. Science 234, 718–725 (1986).

    Article  CAS  Google Scholar 

  13. Qiu, et al. Science 248, 732–735 (1990).

    Article  CAS  Google Scholar 

  14. Kurosaki, et al. Nature 342, 805–807 (1989).

    Article  CAS  Google Scholar 

  15. Muta, et al. Nature 369, 340 (1994).

    Article  CAS  Google Scholar 

  16. Ravetch, et al. Science 290, 84–89 (2000).

    Article  CAS  Google Scholar 

  17. Nimmerjahn, et al. Immunity 23, 41–51 (2005).

    Article  CAS  Google Scholar 

  18. Takai, et al. Cell 76, 519–529 (1994).

    Article  CAS  Google Scholar 

  19. Arthus, M. Seances et Memoire de la Societe de Biologie 55, 817 (1903).

    Google Scholar 

  20. Sylvestre, et al. Science 265, 1095–1098 (1994).

    Article  CAS  Google Scholar 

  21. Wessels, et al. Proc. Natl. Acad. Sci. USA 92, 11490–11494 (1995).

    Article  CAS  Google Scholar 

  22. Sylvestre, et al. J. Exp. Med. 184, 2385–2392 (1996).

    Article  CAS  Google Scholar 

  23. Clynes, et al. Science 279, 1052–1054 (1998).

    Article  CAS  Google Scholar 

  24. Podolanczuk, et al. Blood 113, 3154–3160 (2009).

    Article  CAS  Google Scholar 

  25. Weinblatt, et al. Arthritis Rheum. 58, 3309–3318 (2008).

    Article  CAS  Google Scholar 

  26. Clynes, et al. Nat. Med. 6, 443–446 (2000).

    Article  CAS  Google Scholar 

  27. Cartron, et al. Blood 99, 754–758 (2002).

    Article  CAS  Google Scholar 

  28. Musolino, et al. J. Clin. Oncol. 26, 1789–1796 (2008).

    Article  CAS  Google Scholar 

  29. Takai, et al. Nature 379, 346–349 (1996).

    Article  CAS  Google Scholar 

  30. Bolland, et al. Immunity 13, 277–285 (2000).

    Article  CAS  Google Scholar 

  31. McGaha, et al. Science 307, 590–593 (2005).

    Article  CAS  Google Scholar 

  32. Tsuchiya, et al. Autoimmunity 38, 347–352 (2005).

    Article  CAS  Google Scholar 

  33. Mackay, et al. J. Exp. Med. 203, 2157–2164 (2006).

    Article  CAS  Google Scholar 

  34. Anthony, et al. Proc. Natl. Acad. Sci. USA 105, 19571–19578 (2008).

    Article  CAS  Google Scholar 

  35. Kaneko, et al. Science 313, 670–673 (2006).

    Article  CAS  Google Scholar 

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Acknowledgements

I thank all the students, postdoctoral fellows, technicians and administrative staff who have worked with me over the past 25 years to investigate the complexities of the Fc receptor system, whose insights, hard work and dedication have been invaluable; my colleagues at The Rockefeller University, R. Steinman and M. Nussenzweig, who have been advisors, collaborators; and loyal friends who have made the pursuit of science such a delight. The financial support provided by the National Institutes of Health, donors and philanthropists has allowed this work to progress to the point it has reached today; it is only with their continued support that we can hope to translate this basic work into practical therapies in the future.

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Correspondence to Jeffrey Ravetch.

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Ravetch, J. In vivo veritas: the surprising roles of Fc receptors in immunity. Nat Immunol 11, 183–185 (2010). https://doi.org/10.1038/ni0310-183

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