News and Views
Nature Immunology 9, 227 - 229 (2008)
doi:10.1038/ni0308-227
Itching to end NF-
B
Vigo Heissmeyer1 & Anjana Rao2
- Vigo Heissmeyer is with the Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Molecular Immunology, 81377 Munich, Germany. e-mail: vigo.heissmeyer@helmholtz-muenchen.de
- Anjana Rao is in the Department of Pathology, Harvard Medical School, and Immune Disease Institute, Boston, Massachusetts 02115, USA.
Abstract
Both activation and termination of transcription factor NF-
B signaling require ubiquitin modification of pathway components. The E3 ligase Itch teams up with the NF-B inhibitor A20 to edit the composition of ubiquitin chains on the signaling adaptor RIP, thereby limiting inflammatory responses.
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