In a sea of potential suitors, it is important for T cells to discriminate between self and nonself ligands. New data provide a molecular understanding of how this may be achieved.
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Mueller, D. Tuning the immune system: competing positive and negative feedback loops. Nat Immunol 4, 210–211 (2003). https://doi.org/10.1038/ni0303-210
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DOI: https://doi.org/10.1038/ni0303-210
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