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Granzyme A: the road less traveled

Nature Immunology volume 4, pages 106–108 (2003)Cite this article

Cellular parasites have evolved clever anti-apoptosis strategies to avoid being killed by CTLs. However, CTL release of granzyme A inactivates a key repair enzyme, Ape1, ensuring death of infected cells.

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Figure 1: Cytotoxic granule-mediated “roads to ruin.”

Debbie Maizels

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Authors and Affiliations

  1. Division of Cellular Immunology, La Jolla Institute for Allergy & Immunology, San Diego, 92121, CA, USA

    Michael J. Pinkoski & Douglas R. Green

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  1. Michael J. Pinkoski
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  2. Douglas R. Green
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Pinkoski, M., Green, D. Granzyme A: the road less traveled. Nat Immunol 4, 106–108 (2003). https://doi.org/10.1038/ni0203-106

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