Nature Immunology
4, 13 - 15 (2003)
doi:10.1038/ni0103-13
Checks and balances on developing B cellsTomohiro Kurosaki
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, and Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Moriguchi 570-8506, Japan. kurosaki@mxr.mesh.ne.jp
Signals through the pre-BCR play key roles in B cell development. New data reveal how two downstream components, SLP-65 and the tyrosine kinase Abl, regulate pre-BCR surface expression and immunoglobulin light chain expression.
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