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Glycolytic reprogramming by TLRs in dendritic cells

Nature Immunology volume 15, pages 314–315 (2014)Cite this article

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The activation of dendritic cells by Toll-like receptors leads to a rapid enhancement in glycolysis. Glucose is metabolized to pyruvate and from there to citrate in the mitochondria, which leads ultimately to membrane biosynthesis in the endoplasmic reticulum and Golgi to support the activation of dendritic cells.

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Figure 1: Citrate and DC activation.

References

  1. Krawczyk, C.M. et al. Blood 115, 4742–4749 (2010).

    Article  CAS  Google Scholar 

  2. Tannahill, G.M. et al. Nature 496, 238–242 (2013).

    Article  CAS  Google Scholar 

  3. Infantino, V. et al. Biochem. J. 438, 433–436 (2011).

    Article  CAS  Google Scholar 

  4. Everts, B. et al. Blood 120, 1422–1431 (2012).

    Article  CAS  Google Scholar 

  5. Everts, B. et al. Nat. Immunol. 15, 323–332 (2014).

    Article  CAS  Google Scholar 

  6. Hardie, D.G. & O'Neill, L.A.J. Nature 493, 346–355 (2013).

    Article  Google Scholar 

  7. Ibrahim, J. et al. Gastroenterology 143, 1061–1072 (2012).

    Article  CAS  Google Scholar 

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  1. Luke A.J. O'Neill is with the Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.,

    Luke A J O'Neill

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  1. Luke A J O'Neill
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Correspondence to Luke A J O'Neill.

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O'Neill, L. Glycolytic reprogramming by TLRs in dendritic cells. Nat Immunol 15, 314–315 (2014). https://doi.org/10.1038/ni.2852

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