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IDO: more than an enzyme

In addition to its recognized function as an enzyme that catalyzes tryptophan, indoleamine 2,3-dioxygenase (IDO) acts as an intracellular signal transducer, in response to transforming growth factor-β (TGF-β), to induce a stably regulatory phenotype in plasmacytoid dendritic cells.

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Figure 1: Distinct functions for IDO in pDCs in response to IFN-γ or TGF-β.

Katie Vicari

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Correspondence to WanJun Chen.

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Chen, W. IDO: more than an enzyme. Nat Immunol 12, 809–811 (2011). https://doi.org/10.1038/ni.2088

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