Brief Communication abstract
Nature Genetics 39, 830 - 832 (2007)
Published online: 6 June 2007 | doi:10.1038/ng2061
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Miles Parkes1,13, Jeffrey C Barrett2,13, Natalie J Prescott3,13, Mark Tremelling1, Carl A Anderson2, Sheila A Fisher3, Roland G Roberts3, Elaine R Nimmo4, Fraser R Cummings5, Dianne Soars3, Hazel Drummond4, Charlie W Lees4, Saud A Khawaja3, Richard Bagnall3, Denis A Burke6, Catherine E Todhunter6, Tariq Ahmad5, Clive M Onnie3, Wendy McArdle7, David Strachan8, Graeme Bethel9, Claire Bryan9, Cathryn M Lewis3, Panos Deloukas9, Alastair Forbes10, Jeremy Sanderson11, Derek P Jewell5, Jack Satsangi4, John C Mansfield6, the Wellcome Trust Case Control Consortium12, Lon Cardon2 & Christopher G Mathew3
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 
10-4, combined P = 2.1 10-10) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
- Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, UK.
- Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
- Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London, SE1 9RT, UK.
- Gastrointestinal Unit, Division of Medical Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
- Gastroenterology Unit, Radcliffe Infirmary, University of Oxford, Oxford OX2 6HE, UK.
- Department of Gastroenterology and Hepatology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
- Avon Longitudinal Study of Parents and Children (ALSPAC), University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ, UK.
- Division of Community Health Services, St George's University of London, Cranmer Terrace, London SW17 ORE, UK.
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
- Institute for Digestive Diseases, University College London Hospitals Trust, London NW1 2BU, UK.
- Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
- Wellcome Trust Case Control Consortium.
- These authors contributed equally to this work.
Correspondence to: Miles Parkes1,13 e-mail: miles.parkes@addenbrookes.nhs.uk
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